Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81846 | 0.85 | TSHR (0.55) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL10773059 | 0.80 | TSHR (0.64) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL2959480 | 0.79 | TSHR (0.58) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL7396265 | 0.78 | TSHR (0.61) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL4060135 | 0.78 | TSHR (0.61) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL320278 | 0.73 | LOXL2 (0.54) | CYP11B1CYP11B2TSHRHSD17B10KCNH2 | |
| SCHEMBL10569888 | 0.73 | TSHR (0.68) | TSHRHSD17B10KCNH2KCNJ1ALDH1A1 | |
| SCHEMBL9640908 | 0.73 | TSHR (0.62) | TSHRHSD17B10KCNH2KCNJ1ALDH1A1 | |
| SCHEMBL16582463 | 0.71 | TSHR (0.71) | TSHRHSD17B10KCNH2KCNJ1ALDH1A1 | |
| SCHEMBL16582531 | 0.71 | TSHR (0.71) | TSHRHSD17B10KCNH2KCNJ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |