Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.62 |
| ▸ | NAT1 | P18440 | 3/20 | 0.54 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | MAX | P61244 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971951 | 1.00 | ADAMTS5 (0.62) | ADAMTS5NAT1CISD1MMP13PIK3CG | |
| SCHEMBL7972010 | 0.83 | ADAMTS5 (0.67) | ADAMTS5NAT1CISD1MMP13PIK3CG | |
| SCHEMBL7972014 | 0.83 | ADAMTS5 (0.67) | ADAMTS5NAT1CISD1MMP13PIK3CG | |
| SCHEMBL14151865 | 0.80 | CISD1 (0.76) | ADAMTS5NAT1CISD1MMP13RAB9A | |
| SCHEMBL7968080 | 0.78 | ADAMTS5 (0.58) | ADAMTS5NAT1CISD1NPC1RAB9A | |
| SCHEMBL7968078 | 0.78 | ADAMTS5 (0.58) | ADAMTS5NAT1CISD1NPC1RAB9A | |
| SCHEMBL7972188 | 0.78 | ADAMTS5 (0.77) | ADAMTS5NAT1MMP13GSK3B | |
| SCHEMBL7972192 | 0.78 | ADAMTS5 (0.77) | ADAMTS5NAT1MMP13GSK3B | |
| SCHEMBL14151863 | 0.77 | ADAMTS5 (0.66) | ADAMTS5NAT1CISD1NPC1RAB9A | |
| SCHEMBL14261908 | 0.77 | ADAMTS5 (0.66) | ADAMTS5NAT1CISD1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |