Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.63 |
| ▸ | RXRB | P28702 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | RARB | P10826 | 8/20 | 0.59 |
| ▸ | RARG | P13631 | 8/20 | 0.59 |
| ▸ | RARA | P10276 | 7/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.55 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474035 | 0.90 | TSHR (0.60) | RXRARXRBEGFRLTB4RTSHR | |
| SCHEMBL3550156 | 0.85 | RXRA (0.66) | RXRARXRBEGFRRXRGHCRTR1 | |
| SCHEMBL25125396 | 0.85 | TSHR (0.57) | RXRARXRBEGFRRARBRARG | |
| SCHEMBL9473321 | 0.82 | SYK (0.66) | — | |
| SCHEMBL7505298 | 0.81 | GAA (0.55) | RXRARXRBEGFRRARBRARG | |
| SCHEMBL6536373 | 0.81 | TSHR (0.60) | RXRARXRBEGFRLTB4RTSHR | |
| SCHEMBL5347979 | 0.79 | MEN1 (0.60) | RXRARXRBTSHRRXRGPOLB | |
| SCHEMBL4603368 | 0.79 | PTPN11 (0.59) | RXRARXRBSLC6A9LTB4RTSHR | |
| SCHEMBL1721733 | 0.79 | TSHR (0.62) | RXRARXRBEGFRRARBTSHR | |
| SCHEMBL2746908 | 0.78 | SRD5A2 (0.53) | RXRARXRBEGFRRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288092-B1 | BIPHENYL PYRIDINES, BENZAMIDES AND PENYLCARBOXY COMPOUNDS USED AS SELECTIVE INHIBITORS OF PHOSPHODIESTERASE 4 ISOENZYME ACTIVITY AND DOWN REGULATORS OR INHIBIT TUMOR NECROSIS FACTOR RELEASE; ANTIHISTAMINES AND ANTIINFLAMMATORY | NOVARTIS AG (CH) | 2001-09-11 | — | — | US | disclosed |