Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 10/20 | 0.42 |
| ▸ | PPARG | P37231 | 9/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962734 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2PPARAPPARGTHRATHRB | |
| SCHEMBL7962749 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2PPARAPPARGCYP19A1PTGDR2 | |
| SCHEMBL7962725 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2PPARAPPARGMEN1KMT2A | |
| SCHEMBL7522620 | 0.76 | HSD17B10 (0.51) | METAP1THRATHRBKDM4EMEN1 | |
| SCHEMBL4462617 | 0.75 | METAP1 (0.58) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL7976476 | 0.75 | PPARA (0.42) | SMN1; SMN2PPARAPPARGCYP19A1PTGDR2 | |
| SCHEMBL7972777 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2PPARA | |
| SCHEMBL9136817 | 0.71 | METAP1 (0.42) | METAP1THRATHRBCYP19A1CYP24A1 | |
| SCHEMBL8628473 | 0.71 | AKR1C3 (0.34) | METAP1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL7972644 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2PPARAPPARGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248766-B1 | CARDIOVASCULAR DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-06-19 | — | — | US | disclosed |