Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149609 | 0.95 | MAP3K14 (0.36) | MAP3K14CRBNOR51E2FKBP5GAA | |
| SCHEMBL11539900 | 0.91 | OR51E2 (0.37) | MAP3K14CRBNOR51E2FKBP5KDM4E | |
| SCHEMBL26984176 | 0.91 | OR51E2 (0.37) | MAP3K14CRBNOR51E2FKBP5KDM4E | |
| SCHEMBL797262 | 0.91 | MAP3K14 (0.33) | MAP3K14CRBNOR51E2FKBP5 | |
| SCHEMBL11728785 | 0.89 | MAPT (0.39) | MAP3K14CRBNOR51E2FKBP5KDM4E | |
| SCHEMBL17834527 | 0.78 | TLR4 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL17968884 | 0.78 | TLR4 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL16992089 | 0.77 | OR51E2 (0.35) | MAP3K14CRBNOR51E2FKBP5KDM4E | |
| SCHEMBL22517651 | 0.77 | — | — | |
| SCHEMBL20758331 | 0.77 | CCR5 (0.32) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616074-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2012176123-A1 | 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |