Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15594516 | 0.84 | HDAC8 (0.50) | HDAC8HDAC6NOS2ROCK1SMN1; SMN2 | |
| SCHEMBL7970294 | 0.83 | HDAC8 (0.47) | HDAC8HDAC6ROCK1SMN1; SMN2PSEN1 | |
| SCHEMBL30724682 | 0.82 | HDAC8 (0.54) | HDAC8HDAC6NOS2ROCK1HRH4 | |
| SCHEMBL24982439 | 0.80 | NPC1 (0.46) | NPC1PKMRAB9A | |
| SCHEMBL22010868 | 0.80 | NPC1 (0.46) | NPC1PKMRAB9A | |
| SCHEMBL6490792 | 0.77 | GRM5 (0.54) | HDAC8HDAC6PSEN1PSEN2APH1B | |
| SCHEMBL4058385 | 0.76 | PSEN1 (0.46) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4392502 | 0.76 | SMO (0.53) | SMN1; SMN2GRIN2B | |
| SCHEMBL7909108 | 0.76 | SMO (0.53) | SMN1; SMN2GRIN2B | |
| SCHEMBL8208327 | 0.75 | GBA1 (0.44) | HRH4GBA1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001005767-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2001-01-25 | — | — | WO | claimed |