Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972733 | 0.83 | HDAC8 (0.51) | HDAC8HDAC6PSEN1PSEN2APH1B | |
| SCHEMBL15594429 | 0.81 | KDM4E (0.53) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL30724690 | 0.81 | HDAC8 (0.47) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL30724695 | 0.81 | HDAC8 (0.50) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL30724675 | 0.81 | HDAC8 (0.47) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| Hydrochloric Acid SCHEMBL27142541 | 0.79 | KDM4E (0.52) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL4058385 | 0.77 | PSEN1 (0.46) | KDM4EGAAPSEN1PSEN2APH1B | |
| SCHEMBL30724691 | 0.76 | KDM4E (0.48) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL30724659 | 0.76 | KDM4E (0.48) | HDAC8HDAC6KDM4EGAAMAPK1 | |
| SCHEMBL23500917 | 0.75 | ENPP2 (0.48) | GBA1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001005767-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2001-01-25 | — | — | WO | disclosed |