Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.52 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969445 | 0.80 | KDM1A (0.47) | KDM1AKDM1BPRCPCYP11B2 | |
| SCHEMBL483392 | 0.77 | KDM1A (0.65) | KDM1AKDM1BCYP11B2GRIN2DGRIN3B | |
| SCHEMBL9196424 | 0.73 | KDM1A (0.44) | KDM1AKDM1B | |
| SCHEMBL31554964 | 0.71 | HTR2A (0.46) | KDM1AOPRM1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7333206 | 0.71 | HTR2A (0.46) | KDM1AOPRM1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28611238 | 0.69 | KDM1A (0.96) | KDM1AKDM1BCYP11B2 | |
| SCHEMBL24278848 | 0.68 | KDM1A (0.50) | KDM1AKDM1BCYP11B2GRIN2DGRIN3B | |
| SCHEMBL1478222 | 0.68 | KDM1A (0.50) | KDM1AKDM1BCYP11B2 | |
| SCHEMBL12749373 | 0.68 | KDM1A (0.50) | KDM1AKDM1BCYP11B2 | |
| SCHEMBL24278721 | 0.68 | KDM1A (0.50) | KDM1AKDM1BCYP11B2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0559743-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. | PFIZER HOSPITAL PROD (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009566-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER INC. (US) | 1992-06-11 | — | — | WO | disclosed |