Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.47 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972799 | 0.80 | KDM1A (0.52) | KDM1AKDM1BCYP11B2PRCP | |
| SCHEMBL483392 | 0.72 | KDM1A (0.65) | KDM1AKDM1BHTR2ACYP11B2 | |
| SCHEMBL9196424 | 0.69 | KDM1A (0.44) | KDM1AKDM1B | |
| SCHEMBL28611238 | 0.66 | KDM1A (0.96) | KDM1AKDM1BHTR2ACYP11B2 | |
| SCHEMBL11762259 | 0.66 | MTNR1A (0.66) | HTR2AHRH1HDAC4HDAC7HDAC5 | |
| SCHEMBL3912014 | 0.64 | KDM1A (0.54) | KDM1AKDM1BMAOAHDAC4HDAC7 | |
| SCHEMBL28607219 | 0.64 | KDM1A (0.50) | KDM1AKDM1BMAOACYP11B2HDAC4 | |
| SCHEMBL24278721 | 0.64 | KDM1A (0.50) | KDM1AKDM1BCYP11B2 | |
| SCHEMBL12749373 | 0.64 | KDM1A (0.50) | KDM1AKDM1BCYP11B2 | |
| SCHEMBL24278848 | 0.64 | KDM1A (0.50) | KDM1AKDM1BCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |