Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180587 | 0.91 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL7503358 | 0.89 | EDNRA (0.69) | EDNRAEDNRB | |
| Tezosentan SCHEMBL4524 | 0.89 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL7084660 | 0.89 | EDNRA (0.68) | EDNRAEDNRB | |
| Tezosentan SCHEMBL29409604 | 0.89 | EDNRA (0.80) | EDNRAEDNRB | |
| Tezosentan SCHEMBL387772 | 0.88 | EDNRA (0.79) | EDNRAEDNRB | |
| Tezosentan SCHEMBL6963555 | 0.88 | EDNRA (0.79) | EDNRAEDNRB | |
| Tezosentan SCHEMBL1230886 | 0.88 | EDNRA (0.79) | EDNRAEDNRB | |
| SCHEMBL7974161 | 0.87 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL7962811 | 0.87 | EDNRA (0.80) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081335-A1 | PYRIMIDINE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |