Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972579 | 0.83 | CYP2D6 (0.40) | CYP2D6PTPN1CD274FPR2SCN9A | |
| SCHEMBL8419841 | 0.81 | CYP2D6 (0.47) | CYP2D6GPR6HSD11B1 | |
| Water SCHEMBL7778613 | 0.80 | CYP2D6 (0.46) | CYP2D6CTSBCTSSCTSKCTSC | |
| SCHEMBL7972859 | 0.73 | HSD11B1 (0.49) | CYP2D6HSD11B1 | |
| SCHEMBL1721295 | 0.68 | CYP2D6 (0.67) | CYP2D6GPR6 | |
| Bromide SCHEMBL7777483 | 0.67 | CYP2D6 (0.65) | CYP2D6GPR6 | |
| SCHEMBL28624849 | 0.63 | HTT (0.45) | — | |
| Bromide SCHEMBL7972483 | 0.63 | CYP2D6 (0.58) | CYP2D6GPR6 | |
| SCHEMBL9168347 | 0.62 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL8587416 | 0.62 | NPC1 (0.43) | CYP2D6DRD2DRD4CTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |