Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140052 | 0.88 | TOP1 (0.36) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10140048 | 0.87 | F10 (0.38) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10140047 | 0.86 | F10 (0.40) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7971008 | 0.86 | TNKS (0.45) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10140050 | 0.85 | F10 (0.41) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7966289 | 0.85 | F10 (0.39) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12758112 | 0.85 | TOP1 (0.36) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7970581 | 0.84 | F9 (0.40) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7971397 | 0.83 | ALDH1A1 (0.39) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7960814 | 0.83 | NPC1 (0.39) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |