Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976148 | 1.00 | ALOX5 (0.47) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7973196 | 1.00 | ALOX5 (0.47) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972927 | 0.89 | ALOX5 (0.40) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972676 | 0.89 | ALOX5 (0.40) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972680 | 0.89 | ALOX5 (0.40) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972924 | 0.89 | ALOX5 (0.40) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972679 | 0.89 | ALOX5 (0.40) | ALOX5SLC9A1SRD5A1ALDH1A1POLB | |
| SCHEMBL7972931 | 0.83 | ALOX5 (0.47) | ALOX5ALDH1A1ALOX12SMN1; SMN2MAPT | |
| SCHEMBL7969766 | 0.83 | ALOX5 (0.47) | ALOX5ALDH1A1ALOX12SMN1; SMN2MAPT | |
| SCHEMBL7969764 | 0.83 | ALOX5 (0.47) | ALOX5ALDH1A1ALOX12SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |