Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 13/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388158 | 0.92 | KEAP1 (0.64) | KEAP1NFE2L2MAOBST14LTA4H | |
| SCHEMBL7988040 | 0.92 | KEAP1 (0.64) | KEAP1NFE2L2MAOBST14LTA4H | |
| SCHEMBL23905132 | 0.90 | LTA4H (0.64) | KEAP1NFE2L2MAOBST14LTA4H | |
| SCHEMBL7983918 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2MAOBST14HRH3 | |
| SCHEMBL12990053 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2MAOBST14HRH3 | |
| SCHEMBL7986146 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2MAOBST14HRH3 | |
| SCHEMBL12408533 | 0.90 | KEAP1 (0.62) | KEAP1NFE2L2MAOBST14HRH3 | |
| SCHEMBL9809280 | 0.89 | KEAP1 (0.61) | KEAP1NFE2L2MAOBST14LTA4H | |
| Hydrochloric Acid SCHEMBL6573053 | 0.88 | LTA4H (0.62) | KEAP1NFE2L2MAOBST14LTA4H | |
| SCHEMBL4687513 | 0.88 | KEAP1 (0.60) | KEAP1NFE2L2MAOBST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221914-B1 | ANTIINFLAMMATORY AGENTS | ARRAY BIOPHARMA INC. | 2001-04-24 | — | — | US | disclosed |