Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645603 | 0.80 | KDM4E (0.45) | HTR2A | |
| SCHEMBL73543 | 0.78 | AOC3 (0.47) | SLC6A3SLC6A4CHRNA7 | |
| SCHEMBL7203954 | 0.78 | HRH4 (0.53) | VCPHTR2ACHRNA7HRH3HRH4 | |
| SCHEMBL7968720 | 0.76 | HTR2A (0.47) | SLC6A3SLC6A2HTR2ASLC6A4KCNH2 | |
| SCHEMBL12534038 | 0.76 | AOC3 (0.41) | SLC6A3SLC6A4 | |
| SCHEMBL7447996 | 0.75 | CHRNA7 (0.41) | SLC6A3SLC6A2VCPHTR2ASLC6A4 | |
| SCHEMBL7448151 | 0.75 | CHRNA7 (0.41) | SLC6A3SLC6A2VCPHTR2ASLC6A4 | |
| SCHEMBL3640169 | 0.75 | AOC3 (0.44) | — | |
| SCHEMBL7498418 | 0.74 | PARP1 (0.42) | VCPHTR2ASLC6A4CHRM2CHRM4 | |
| SCHEMBL10441226 | 0.74 | AOC3 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001014374-A2 | PROCESSES FOR THE PREPRATION OF EXO- AND ENDO-INDOLOTROPANES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-03-01 | — | — | WO | disclosed |