Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121313 | 0.96 | HTR2A (0.52) | HTR2AMAPTMEN1KMT2ANR1I2 | |
| SCHEMBL28092143 | 0.91 | MAPT (0.55) | HTR2AMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL16430337 | 0.85 | MAPT (0.64) | HTR2AMAPTMEN1KMT2ANR1I2 | |
| SCHEMBL15295021 | 0.85 | CYP1A2 (0.59) | HTR2AMAPTMEN1KMT2ALMNA | |
| SCHEMBL26640241 | 0.85 | GAA (0.51) | HTR2AMAPTMEN1KMT2AGAA | |
| SCHEMBL24074336 | 0.85 | ALDH1A1 (0.56) | HTR2AMAPTKMT2AGAAALDH1A1 | |
| SCHEMBL27518516 | 0.84 | MAPT (0.67) | HTR2AMAPTMEN1KMT2ANR1I2 | |
| SCHEMBL12972414 | 0.83 | MAPT (0.59) | MAPTMEN1KMT2ANR1I2LMNA | |
| SCHEMBL9697401 | 0.83 | CA12 (0.51) | MAPTMEN1KMT2ANR1I2LMNA | |
| SCHEMBL5208038 | 0.83 | PDE4A (0.46) | HTR2AMAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001046171-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001046170-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |