Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974305 | 0.93 | MAPT (0.53) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7975380 | 0.93 | LMNA (0.47) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7974465 | 0.92 | LMNA (0.47) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7964021 | 0.92 | LMNA (0.47) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7977567 | 0.91 | LMNA (0.47) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7977583 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7964043 | 0.91 | MAPT (0.50) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7977585 | 0.91 | POLB (0.48) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7975451 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1MAPTRAB9ALMNA | |
| SCHEMBL7980362 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |