Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974397 | 0.91 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7974305 | 0.85 | MAPT (0.53) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7975380 | 0.84 | LMNA (0.47) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7963977 | 0.84 | LMNA (0.49) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7975313 | 0.84 | LMNA (0.44) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7964021 | 0.83 | LMNA (0.47) | POLBSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7974465 | 0.83 | LMNA (0.47) | POLBSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7977583 | 0.82 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7977567 | 0.82 | LMNA (0.47) | POLBSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7964043 | 0.82 | MAPT (0.50) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |