Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 9/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.75 |
| ▸ | HTT | P42858 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797443 | 1.00 | ALDH1A1 (0.75) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8758274 | 0.86 | ALDH1A1 (0.81) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8986638 | 0.86 | ALDH1A1 (0.81) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8758840 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8986557 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8758340 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL8986604 | 0.85 | ALDH1A1 (1.00) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL15471749 | 0.84 | ALDH1A1 (0.81) | ALDH1A1MAPTNPSR1HTTKMT2A | |
| SCHEMBL797463 | 0.84 | ALDH1A1 (0.69) | ALDH1A1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL20605312 | 0.81 | MAPT (0.79) | ALDH1A1MAPTNPSR1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946260-B2 | 17α-hydroxylase/C17,20-lyase inhibitors | NOVARTIS AG (CH) | 2015-02-03 | — | — | US | disclosed |
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2014-02-13 | — | — | US | disclosed |
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | CYP17A1, CYP21A2, HSD17B1 | ALDH1A1 68/4885MAPT 3507/4885NPSR1 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.