Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975322 | 0.78 | POLB (0.31) | BACE1 | |
| SCHEMBL7994077 | 0.75 | PDCD1 (0.46) | FGFR1KDM4EMAPK1 | |
| SCHEMBL7234154 | 0.73 | CYP3A4 (0.41) | BACE1 | |
| SCHEMBL29387450 | 0.72 | BACE1 (0.48) | BACE1 | |
| SCHEMBL4680048 | 0.71 | BACE1 (0.40) | BACE1KDM4E | |
| SCHEMBL2750402 | 0.70 | BACE1 (0.47) | BACE1 | |
| SCHEMBL7391015 | 0.70 | BACE1 (0.44) | BACE1KDM4E | |
| SCHEMBL15389825 | 0.69 | BACE1 (0.42) | BACE1 | |
| SCHEMBL3909826 | 0.68 | BACE1 (0.43) | BACE1 | |
| SCHEMBL31371104 | 0.67 | IDO1 (0.53) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |
| WO-2001034578-A1 | COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |