SCHEMBL7975322

SCHEMBL7975322

Cc1c(CO[Si](C)(C)C(C)(C)C)cccc1SCCn1ncnn1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7974535 0.78 BACE1 (0.37) BACE1
SCHEMBL7983842 0.72 GAA (0.38) POLB
SCHEMBL7234154 0.66 CYP3A4 (0.41) BACE1
SCHEMBL7994549 0.62 LMNA (0.45) POLB
SCHEMBL15389825 0.62 BACE1 (0.42) BACE1
SCHEMBL29387450 0.62 BACE1 (0.48) BACE1
SCHEMBL7391015 0.60 BACE1 (0.44) BACE1
SCHEMBL5467148 0.60 BACE1 (0.39) BACE1
SCHEMBL1467137 0.60 BACE1 (0.37) POLBBACE1
SCHEMBL28999268 0.59 RAB9A (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001034573-A1 COMPOUNDS ASTRAZENECA AB (SE) 2001-05-17 WO disclosed
WO-2001034578-A1 COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY ASTRAZENECA AB (SE) 2001-05-17 WO disclosed