Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | DHODH | Q02127 | 3/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MASP2 | O00187 | 1/20 | 0.53 |
| ▸ | CFD | P00746 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936398 | 0.88 | DHODH (0.64) | KMT2ADHODHTRPM8MAPTCTSK | |
| SCHEMBL27971661 | 0.86 | KDM4E (0.59) | KMT2AMAPTPKMMEN1LMNA | |
| SCHEMBL6326283 | 0.86 | KMT2A (0.62) | KMT2ADHODHTRPM8MAPTCTSK | |
| SCHEMBL30583240 | 0.84 | PTPN1 (0.64) | KMT2ADHODHTRPM8TRPA1PKM | |
| SCHEMBL4315667 | 0.84 | PTPN1 (0.64) | KMT2ADHODHTRPM8TRPA1PKM | |
| SCHEMBL27580953 | 0.84 | ALDH1A1 (0.59) | KMT2AMAPTTRPA1PKMMEN1 | |
| SCHEMBL11132128 | 0.83 | NPC1 (0.52) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL7846234 | 0.83 | KMT2A (0.55) | KMT2ADHODHTRPM8MAPTCTSK | |
| SCHEMBL3627546 | 0.81 | MASP2 (0.62) | KMT2ADHODHMAPTCTSKPKM | |
| SCHEMBL233797 | 0.81 | KMT2A (0.57) | KMT2ADHODHTRPM8MAPTCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |