Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977479 | 0.86 | NPC1 (0.44) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7977587 | 0.82 | NPC1 (0.58) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7964032 | 0.81 | NPC1 (0.60) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7974288 | 0.80 | KMT2A (0.65) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7964015 | 0.80 | EPHX2 (0.64) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7964004 | 0.78 | NPC1 (0.55) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7963996 | 0.78 | HPGD (0.56) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7977605 | 0.76 | SMN1; SMN2 (0.51) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7974453 | 0.76 | NPC1 (0.50) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7977633 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |