Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974288 | 0.91 | KMT2A (0.65) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7977633 | 0.88 | SMN1; SMN2 (0.56) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7964032 | 0.85 | NPC1 (0.60) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7964015 | 0.84 | EPHX2 (0.64) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7977571 | 0.84 | NPC1 (0.53) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL7974434 | 0.84 | POLB (0.65) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7974413 | 0.84 | SMN1; SMN2 (0.59) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7963947 | 0.84 | RAB9A (0.70) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL7980296 | 0.84 | SMN1; SMN2 (0.57) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL7980161 | 0.84 | RAB9A (0.50) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |