Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Mercaptobenzimidazole SCHEMBL7975305 | 0.94 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7977587 | 0.88 | NPC1 (0.58) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7974288 | 0.88 | KMT2A (0.65) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7977571 | 0.83 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7974434 | 0.83 | POLB (0.65) | SMN1; SMN2RAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL7974413 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL7980161 | 0.83 | RAB9A (0.50) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7963873 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1LMNARECQL | |
| SCHEMBL7964027 | 0.82 | POLB (0.71) | RAB9ANPC1LMNAALDH1A1HTT | |
| SCHEMBL7977544 | 0.82 | LMNA (0.57) | SMN1; SMN2RAB9ANPC1LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |