Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 16/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 16/20 | 1.00 |
| ▸ | RELA | Q04206 | 16/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961876 | 0.79 | NFKB1 (0.76) | NFKB1NFKB2RELAKDM4EPKM | |
| SCHEMBL7975362 | 0.79 | NFKB1 (1.00) | NFKB1NFKB2RELAKDM4EPKM | |
| SCHEMBL7962069 | 0.78 | NFKB1 (0.83) | NFKB1NFKB2RELAKDM4EPKM | |
| SCHEMBL7975488 | 0.77 | NFKB1 (0.81) | NFKB1NFKB2RELAKDM4EPKM | |
| SCHEMBL7971965 | 0.77 | NFKB1 (1.00) | NFKB1NFKB2RELAKDM4EPKM | |
| SCHEMBL4332607 | 0.71 | NFKB1 (0.56) | NFKB1NFKB2RELAKDM4ERAB9A | |
| SCHEMBL7961832 | 0.71 | NFKB1 (1.00) | NFKB1NFKB2RELAABCB1 | |
| SCHEMBL7973436 | 0.66 | NFKB1 (0.54) | NFKB1NFKB2RELAABCB1 | |
| SCHEMBL4324613 | 0.66 | NFKB1 (0.49) | NFKB1NFKB2RELAMAPK1RAB9A | |
| SCHEMBL31238159 | 0.66 | SMN1; SMN2 (0.81) | KDM4EPKMMAPK1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001072735-A2 | BENZOPYRANES USEFUL AS TNF ALPHA INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-10-04 | — | — | WO | disclosed |