Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pradofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 3/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8741063 | 0.92 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7976296 | 0.92 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7545022 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL2201509 | 0.90 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL150884 | 0.90 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7488977 | 0.90 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7678035 | 0.90 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL30595280 | 0.89 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Pradofloxacin SCHEMBL7962325 | 0.89 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7975584 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323213-B1 | ANTIBIOTICS, BACTERICIDES FOR VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-11-27 | — | — | US | disclosed |
| US-6278013-B1 | AS CHEMICAL INTERMEDIATES FOR PREPARING QUINOLINECARBOXYLIC ACID DERIVATIVE ANTIBIOTICS USED IN VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-21 | — | — | US | disclosed |