SCHEMBL7975893

SCHEMBL7975893

CCc1cc(O)cc(C)c1OCCCNC(=O)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.52
ALDH1A1 P00352 2/20 0.47
HSP90AA1 P07900 1/20 0.46
KMT2A Q03164 3/20 0.45
MEN1 O00255 1/20 0.45
RHOC P08134 1/20 0.45
RHOA P61586 1/20 0.45
RAB9A P51151 3/20 0.44
CYP1A2 P05177 2/20 0.44
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
GFER P55789 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NAMPT P43490 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
TSHR P16473 1/20 0.43
NFKB1 P19838 1/20 0.43
MAOB P27338 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979318 0.97 NPC1 (0.48) NPC1ALDH1A1HSP90AA1KMT2AMEN1
SCHEMBL7981926 0.88 NPC1 (0.54) NPC1ALDH1A1HSP90AA1KMT2AMEN1
SCHEMBL7978800 0.88 SMN1; SMN2 (0.49) NPC1ALDH1A1KMT2AMEN1RAB9A
SCHEMBL7979330 0.87 PPARD (0.46) NPC1ALDH1A1KMT2ARHOCRHOA
SCHEMBL7965653 0.85 NAAA (0.51) NPC1KMT2AMEN1RAB9ASMN1; SMN2
SCHEMBL7979257 0.85 NPC1 (0.50) NPC1ALDH1A1HSP90AA1KMT2AMEN1
SCHEMBL7981831 0.84 HDAC3 (0.49) NPC1KMT2ARAB9AL3MBTL1
SCHEMBL7979214 0.84 PPARD (0.48) NPC1ALDH1A1RHOCRHOARAB9A
SCHEMBL7977626 0.82 NPC1 (0.53) NPC1ALDH1A1HSP90AA1KMT2AMEN1
SCHEMBL8060866 0.81 NPC1 (0.47) NPC1ALDH1A1HSP90AA1KMT2ARHOC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed
US-6028100-A Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-22 US disclosed
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
CN-1187809-A Dihalopropene compound, insecticide containing the same as active ingredient, and production intermediate thereof SUMITOMO CHEMICAL CO (JP) 1998-07-15 CN disclosed
EP-0824514-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-02-25 EP disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed