Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959659 | 1.00 | ALOX5 (0.42) | ALOX5SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL7959661 | 1.00 | ALOX5 (0.42) | ALOX5SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL7959163 | 0.82 | ALOX5 (0.43) | ALOX5SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL12512575 | 0.78 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL18231892 | 0.76 | SLC6A3 (0.40) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL12512449 | 0.75 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL13795283 | 0.75 | SLC6A3 (0.51) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL13795239 | 0.74 | SLC6A3 (0.50) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL12511662 | 0.74 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C | |
| SCHEMBL13795674 | 0.74 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4CYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |