Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975918 | 1.00 | ALOX5 (0.47) | ALOX5KDM1ASLC9A1SLC6A2HTR2A | |
| SCHEMBL7959780 | 0.83 | ALOX5 (0.64) | ALOX5KDM1ASLC9A1SLC6A2HTR2A | |
| SCHEMBL7972814 | 0.83 | ALOX5 (0.64) | ALOX5KDM1ASLC9A1SLC6A2HTR2A | |
| SCHEMBL7959777 | 0.83 | ALOX5 (0.64) | ALOX5KDM1ASLC9A1SLC6A2HTR2A | |
| SCHEMBL7973144 | 0.80 | MGLL (0.39) | ALOX5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7973141 | 0.80 | MGLL (0.39) | ALOX5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9163645 | 0.79 | ALOX5 (0.79) | ALOX5PARP10 | |
| SCHEMBL9163641 | 0.79 | ALOX5 (0.79) | ALOX5PARP10 | |
| SCHEMBL7972861 | 0.76 | ALOX5 (0.56) | ALOX5KDM1ASLC9A1MAP1LC3BPARP10 | |
| SCHEMBL7959762 | 0.73 | ALOX5 (0.53) | ALOX5KDM1ASLC9A1MAP1LC3BPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |