Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | APLNR | P35414 | 5/20 | 0.38 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976015 | 0.89 | EDNRA (0.44) | EDNRAAPLNRKMT2AMEN1HPGD | |
| SCHEMBL7986434 | 0.83 | EDNRA (0.41) | EDNRAAPLNREDNRBKMT2ASCD5 | |
| SCHEMBL7986738 | 0.82 | MAPK1 (0.43) | KMT2AMEN1HTT | |
| SCHEMBL7994192 | 0.81 | EDNRA (0.41) | EDNRAAPLNREDNRBSCD5MAPT | |
| SCHEMBL7990304 | 0.79 | MEN1 (0.42) | KMT2AMEN1MAPT | |
| SCHEMBL7986399 | 0.78 | EDNRA (0.42) | EDNRAEDNRBKMT2ASCD5MAPT | |
| SCHEMBL7989782 | 0.76 | EDNRA (0.44) | EDNRAAPLNRMAPTALDH1A1 | |
| SCHEMBL7994654 | 0.74 | EDNRA (0.44) | EDNRAMAPTALDH1A1 | |
| SCHEMBL7987573 | 0.74 | EDNRA (0.44) | EDNRAEDNRBKMT2AMEN1HPGD | |
| Hydrochloric Acid SCHEMBL7987566 | 0.74 | MAPK9 (0.39) | EDNRAAPLNRKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |