Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986399 | 0.93 | EDNRA (0.42) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7986434 | 0.91 | EDNRA (0.41) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7994192 | 0.91 | EDNRA (0.41) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7987522 | 0.88 | EDNRA (0.47) | EDNRAKMT2AMAPTHPGDMEN1 | |
| SCHEMBL7994175 | 0.83 | EDNRA (0.35) | EDNRASCD5MAPTOGACYP26A1 | |
| SCHEMBL7990070 | 0.81 | MAPK1 (0.47) | KMT2AMEN1HTT | |
| SCHEMBL7989782 | 0.81 | EDNRA (0.44) | EDNRAMAPTNPC1RAB9A | |
| SCHEMBL7994654 | 0.80 | EDNRA (0.44) | EDNRAMAPTNPC1RAB9A | |
| SCHEMBL7986613 | 0.77 | EDNRA (0.34) | EDNRASCD5EDNRBMAPTHPGD | |
| SCHEMBL7989806 | 0.77 | EDNRA (0.40) | EDNRAMAPTPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |