Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.36 |
| ▸ | ITGAV | P06756 | 7/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.36 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986434 | 0.97 | EDNRA (0.41) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7986399 | 0.94 | EDNRA (0.42) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7987573 | 0.91 | EDNRA (0.44) | EDNRAMAPK9AKR1C3AKR1C2SCD5 | |
| SCHEMBL7994654 | 0.89 | EDNRA (0.44) | EDNRAMAPTALDH1A1 | |
| SCHEMBL7989782 | 0.87 | EDNRA (0.44) | EDNRAAPLNRMAPTALDH1A1 | |
| SCHEMBL7975894 | 0.85 | IL6ST (0.36) | EDNRASCD5ITGB3ITGAVITGA2B | |
| SCHEMBL7989806 | 0.83 | EDNRA (0.40) | EDNRAITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7986462 | 0.83 | MAPK1 (0.44) | — | |
| SCHEMBL7986429 | 0.82 | IL6ST (0.35) | EDNRASCD5ITGB3ITGAVITGA2B | |
| SCHEMBL7975989 | 0.81 | EDNRA (0.41) | EDNRASCD5APLNRMAPTEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |