Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 6/20 | 0.53 |
| ▸ | IL1RN | P18510 | 5/20 | 0.53 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.53 |
| ▸ | TACR1 | P25103 | 8/20 | 0.50 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NMBR | P28336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993776 | 0.93 | ERAP2 (0.52) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7990279 | 0.93 | LMNA (0.58) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7990652 | 0.90 | ERAP1 (0.52) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7975820 | 0.88 | IL1RN (0.55) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7986576 | 0.88 | IL1RN (0.55) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7993348 | 0.88 | IL1RN (0.55) | ERAP1IL1RNERAP2TACR1LNPEP | |
| SCHEMBL7990312 | 0.87 | ITGB2 (0.49) | ERAP1IL1RNERAP2 | |
| SCHEMBL7993685 | 0.83 | ECE1 (0.55) | — | |
| SCHEMBL7986482 | 0.82 | ITGB2 (0.57) | — | |
| SCHEMBL7975904 | 0.80 | ITGB2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |