Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | TPMT | P51580 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20223086 | 0.94 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL5449774 | 0.83 | PDE4A (0.47) | L3MBTL1ALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL3546502 | 0.81 | MAPT (0.63) | ALDH1A1CYP2C9CYP2C19HPGDHSD17B10 | |
| SCHEMBL30037363 | 0.81 | MAPT (0.63) | ALDH1A1CYP2C9CYP2C19HPGDHSD17B10 | |
| SCHEMBL2997461 | 0.80 | TSHR (0.77) | L3MBTL1ALDH1A1CYP2C9CYP2C19TSHR | |
| SCHEMBL29594225 | 0.80 | MAPT (0.58) | L3MBTL1ALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL21385340 | 0.80 | MAPT (0.58) | L3MBTL1ALDH1A1CYP2C9CYP2C19HPGD | |
| SCHEMBL29399077 | 0.80 | TSHR (0.73) | L3MBTL1ALDH1A1CYP2C9CYP2C19TSHR | |
| SCHEMBL76834 | 0.80 | TSHR (0.73) | L3MBTL1ALDH1A1CYP2C9CYP2C19TSHR | |
| SCHEMBL27753902 | 0.80 | TSHR (0.73) | L3MBTL1ALDH1A1CYP2C9CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |
| US-4178442-A | ANTIANGOROUS ACTIVITY | DELALANDE S. A. (FR) | 1979-12-11 | — | — | US | disclosed |