Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594225 | 1.00 | MAPT (0.58) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL3546502 | 0.94 | MAPT (0.63) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL30037363 | 0.94 | MAPT (0.63) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL13495915 | 0.88 | NOTUM (0.51) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL4217151 | 0.88 | MGLL (0.51) | MAPTKMT2AALDH1A1CYP2C9CA12 | |
| SCHEMBL6296439 | 0.84 | MAPT (0.44) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL8099482 | 0.82 | ALDH1A1 (0.54) | MAPTKMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20223086 | 0.80 | ALDH1A1 (0.55) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL7976202 | 0.80 | L3MBTL1 (0.59) | MAPTKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL5240311 | 0.79 | MEN1 (0.49) | MAPTKMT2AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311528-B2 | Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors | MERCK SHARP & DOHME CORP. (US) | 2022-04-26 | — | — | US | disclosed |
| US-11311528-B2 | Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors | MERCK SHARP & DOHME CORP. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210052573-A1 | OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-02-25 | — | — | US | disclosed |
| US-20210052573-A1 | OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-02-25 | — | — | US | disclosed |
| EP-3768266-A1 | OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019182886-A1 | OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11311528-B2 | Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors | STING1, MAVS, CGAS | MAPT 4074/4885KMT2A 3512/4885ALDH1A1 4060/4885 |
| US-20210052573-A1 | OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS | STING1, MAVS, CGAS | MAPT 4074/4885KMT2A 3512/4885ALDH1A1 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.