Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.54 |
| ▸ | PRKCA | P17252 | 10/20 | 0.53 |
| ▸ | PRKCB | P05771 | 4/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.46 |
| ▸ | PRKCG | P05129 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990678 | 0.91 | GSK3B (0.59) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7977136 | 0.86 | GSK3B (0.57) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7530443 | 0.86 | GSK3B (0.72) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7976571 | 0.85 | GSK3B (0.56) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7976579 | 0.85 | GSK3B (0.56) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7976147 | 0.85 | GSK3B (0.56) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7990286 | 0.85 | GSK3B (0.52) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7499657 | 0.84 | GSK3B (0.70) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7526149 | 0.83 | GSK3B (0.53) | GSK3BPRKCAPRKCBPRKCEPRKCG | |
| SCHEMBL7987080 | 0.83 | GSK3B (0.54) | GSK3BPRKCAPRKCBPRKCEPRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |