Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.72 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.63 |
| ▸ | CDK4 | P11802 | 1/20 | 0.63 |
| ▸ | CCND1 | P24385 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.63 |
| ▸ | PRKCB | P05771 | 5/20 | 0.59 |
| ▸ | PRKCA | P17252 | 5/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.59 |
| ▸ | PRKCG | P05129 | 6/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990993 | 0.90 | CDK2 (0.67) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7976776 | 0.90 | CDK4 (0.67) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7977136 | 0.89 | GSK3B (0.57) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7986966 | 0.89 | PRKACA (0.66) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7987101 | 0.89 | CDK4 (0.66) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7987757 | 0.89 | CCNE2 (0.66) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL6586180 | 0.89 | GSK3B (0.69) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7976147 | 0.88 | GSK3B (0.56) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7976571 | 0.88 | GSK3B (0.56) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7976579 | 0.88 | GSK3B (0.56) | GSK3BCDK2CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |