Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SLC29A1 | Q99808 | 12/20 | 0.60 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE8A | O60658 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970119 | 0.78 | SLC29A1 (0.66) | MAPTMAPK1SLC29A1MEN1KMT2A | |
| SCHEMBL11874405 | 0.78 | MAPT (0.93) | MAPTMAPK1SETDB1MEN1KMT2A | |
| SCHEMBL7976583 | 0.75 | SLC29A1 (0.71) | MAPTSLC29A1MEN1KMT2AKDM4E | |
| SCHEMBL7971739 | 0.74 | SLC29A1 (0.60) | MAPTSLC29A1MEN1KMT2AKDM4E | |
| SCHEMBL7960351 | 0.72 | SLC29A1 (0.61) | MAPTSLC29A1MEN1KMT2AKDM4E | |
| SCHEMBL7971382 | 0.72 | HTT (0.60) | MAPTSLC29A1MEN1KMT2AKDM4E | |
| SCHEMBL7951223 | 0.71 | SLC29A1 (0.41) | MAPTMAPK1SLC29A1MEN1KMT2A | |
| SCHEMBL7947717 | 0.70 | SLC29A1 (0.86) | MAPTSLC29A1MEN1KMT2AKDM4E | |
| SCHEMBL23181 | 0.70 | MAPK1 (0.55) | MAPTMAPK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7953158 | 0.69 | SLC29A1 (0.74) | MAPTSLC29A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |