Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976099 | 0.94 | GAA (0.51) | SMN1; SMN2GAANPSR1KDM4EHSD17B10 | |
| SCHEMBL9081734 | 0.91 | LMNA (0.46) | GAAKDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL7994043 | 0.85 | HPGD (0.50) | GAANPSR1KDM4EHSD17B10HPGD | |
| SCHEMBL5356914 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2GAANPSR1KDM4EHSD17B10 | |
| SCHEMBL1573002 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2GAANPSR1KDM4EHSD17B10 | |
| SCHEMBL707685 | 0.78 | GAA (0.64) | GAANPSR1KDM4EHSD17B10HPGD | |
| SCHEMBL21241110 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2GAANPSR1KDM4EHSD17B10 | |
| SCHEMBL9701615 | 0.76 | KMT2A (0.59) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5960627 | 0.76 | ALDH1A1 (0.56) | GAAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL25824251 | 0.76 | GAA (0.53) | SMN1; SMN2GAANPSR1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |