Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990043 | 0.90 | ALDH1A1 (0.57) | TDP1L3MBTL1LMNAALDH1A1MAPK1 | |
| SCHEMBL7949126 | 0.85 | L3MBTL1 (0.58) | TDP1L3MBTL1LMNAHTTALDH1A1 | |
| SCHEMBL31621042 | 0.85 | ALDH1A1 (0.51) | TDP1L3MBTL1ALDH1A1MAPK1CASP7 | |
| SCHEMBL9943157 | 0.78 | L3MBTL1 (0.70) | TDP1L3MBTL1LMNAHTTALDH1A1 | |
| SCHEMBL28296720 | 0.78 | L3MBTL1 (0.60) | TDP1L3MBTL1LMNAHTTALDH1A1 | |
| SCHEMBL1437881 | 0.77 | L3MBTL1 (0.62) | TDP1L3MBTL1LMNAHTTALDH1A1 | |
| SCHEMBL2212705 | 0.77 | AKR1C3 (0.68) | TDP1L3MBTL1HTTALDH1A1MAPK1 | |
| SCHEMBL6179431 | 0.77 | AKR1C3 (0.74) | TDP1L3MBTL1LMNAALDH1A1MAPK1 | |
| SCHEMBL4589360 | 0.77 | MAPK1 (0.55) | TDP1L3MBTL1LMNAHTTALDH1A1 | |
| SCHEMBL27470880 | 0.75 | MEN1 (0.70) | TDP1L3MBTL1HTTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |