Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548699 | 0.94 | KDR (0.54) | KDRFLT1FLT4SCN7ASLC6A4 | |
| SCHEMBL7990347 | 0.92 | KDR (0.53) | KDRFLT1FLT4SLC6A4HRH3 | |
| SCHEMBL7555484 | 0.90 | KDR (0.59) | KDRFLT1FLT4SCN7AHRH3 | |
| SCHEMBL7987947 | 0.90 | KDR (0.52) | KDRFLT1FLT4SCN7AHRH3 | |
| SCHEMBL7555601 | 0.89 | KDR (0.58) | KDRFLT1FLT4SIGMAR1MCHR1 | |
| SCHEMBL7987153 | 0.88 | KDR (0.50) | KDRFLT1FLT4SCN7AHRH3 | |
| SCHEMBL7553614 | 0.86 | KDR (0.55) | KDRFLT1FLT4SLC6A4MCHR1 | |
| SCHEMBL7555658 | 0.85 | KDR (0.73) | KDRFLT1FLT4SCN7ASIGMAR1 | |
| SCHEMBL7547180 | 0.85 | KDR (0.60) | KDRFLT1FLT4HRH3HRH2 | |
| SCHEMBL7552695 | 0.85 | KDR (0.54) | KDRFLT1FLT4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |