Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552695 | 0.95 | KDR (0.54) | KDRFLT1FLT4HRH3 | |
| SCHEMBL7991259 | 0.92 | KDR (0.53) | KDRFLT1FLT4FNTAFNTB | |
| SCHEMBL7976563 | 0.90 | KDR (0.52) | KDRFLT1FLT4HRH3SCN7A | |
| SCHEMBL7555484 | 0.90 | KDR (0.59) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7551512 | 0.90 | KDR (0.58) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7551942 | 0.87 | KDR (0.55) | KDRFLT1FLT4HRH3 | |
| SCHEMBL7504415 | 0.87 | KDR (0.50) | KDRFLT1FLT4FNTAFNTB | |
| SCHEMBL7553508 | 0.86 | KDR (0.69) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7548699 | 0.85 | KDR (0.54) | KDRFLT1FLT4HRH3SCN7A | |
| SCHEMBL7547180 | 0.84 | KDR (0.60) | KDRFLT1FLT4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |