Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 14/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.51 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | MAX | P61244 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455550 | 0.89 | ITGAV (0.51) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7455544 | 0.89 | ITGAV (0.51) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL6016242 | 0.84 | ITGAV (0.53) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7450546 | 0.83 | ITGB3 (0.47) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7446807 | 0.83 | ITGAV (0.62) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7444601 | 0.79 | ITGAV (0.43) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7455940 | 0.79 | ITGAV (0.47) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7456099 | 0.78 | ITGAV (0.42) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7455933 | 0.76 | ITGAV (0.45) | ITGAVITGB3ITGA2BITGB1ITGA5 | |
| SCHEMBL7354167 | 0.75 | ITGAV (0.47) | ITGAVITGB3ITGA2BITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274620-B1 | 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION | BIOCHEM PHARMA INC. (CA) | 2001-08-14 | — | — | US | disclosed |