Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 8/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966576 | 0.86 | EGFR (0.57) | CYP1A2CYP3A4LMNAHIF1AMAPK1 | |
| SCHEMBL7983292 | 0.83 | EGFR (0.67) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL27545981 | 0.82 | EGFR (0.69) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7978607 | 0.82 | EGFR (0.60) | RAF1EGFRFLT1KDRERBB2 | |
| Hydrochloric Acid SCHEMBL7539353 | 0.82 | EGFR (0.67) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7124447 | 0.81 | FLT1 (0.81) | EGFRFLT1KDR | |
| SCHEMBL7980576 | 0.80 | EGFR (0.66) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7535216 | 0.80 | EGFR (0.65) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL8093519 | 0.79 | EGFR (1.00) | EGFRPIK3CAPIK3CGFLT1ERBB2 | |
| SCHEMBL3606262 | 0.79 | EGFR (0.73) | EGFRPIK3CAPIK3CGFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | claimed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |