Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 8/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976753 | 0.80 | CYP1A2 (0.66) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7983292 | 0.80 | EGFR (0.67) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL8093519 | 0.80 | EGFR (1.00) | EGFRPIK3CAPIK3CGFLT1ERBB2 | |
| SCHEMBL1733829 | 0.79 | EGFR (0.76) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL3606262 | 0.77 | EGFR (0.73) | EGFRPIK3CAPIK3CGFLT1KDR | |
| SCHEMBL7976817 | 0.77 | HPGD (0.62) | EGFRPIK3CAPIK3CGFLT1ERBB2 | |
| SCHEMBL7127189 | 0.76 | EGFR (0.66) | EGFRPIK3CAPIK3CGFLT1KDR | |
| Hydrochloric Acid SCHEMBL8593958 | 0.76 | EGFR (0.72) | EGFRFLT1KDR | |
| SCHEMBL8976304 | 0.76 | EGFR (0.71) | EGFRPIK3CAPIK3CGFLT1IRAK4 | |
| Hydrochloric Acid SCHEMBL8976403 | 0.76 | EGFR (0.67) | EGFRPIK3CAPIK3CGFLT1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |