Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605322 | 0.78 | TDP1 (0.45) | NOS2MIFLMNAHIF1AKDM4E | |
| SCHEMBL5219001 | 0.76 | NOS2 (0.43) | NOS2ALOX5MIFLMNACYP2D6 | |
| SCHEMBL7020087 | 0.74 | NOS2 (0.70) | NOS2ALOX5MIFTAAR1ADRA2A | |
| Acetic Acid SCHEMBL11168239 | 0.73 | NOS2 (0.62) | NOS2ALOX5MIFLMNACYP2C19 | |
| Isopropylbenzene SCHEMBL10933955 | 0.73 | ALOX5 (0.55) | NOS2ALOX5ADRA2AADRA2CLMNA | |
| Isopropylbenzene SCHEMBL17187547 | 0.73 | ALOX5 (0.55) | NOS2ALOX5ADRA2AADRA2CLMNA | |
| SCHEMBL23052844 | 0.72 | ALOX5 (0.55) | NOS2ALOX5ADRA2AADRA2CLMNA | |
| SCHEMBL362440 | 0.72 | ALOX5 (0.55) | NOS2ALOX5ADRA2AADRA2CLMNA | |
| SCHEMBL14355196 | 0.72 | NOS2 (0.96) | NOS2ALOX5MIFADRA2AADRA2C | |
| SCHEMBL20260341 | 0.72 | ALOX5 (0.55) | NOS2ALOX5ADRA2AADRA2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | claimed |
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |