Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12323197 | 0.91 | POLB (0.69) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL12768686 | 0.89 | POLB (0.67) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL12768681 | 0.89 | POLB (0.67) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL12768688 | 0.89 | POLB (0.67) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL12768690 | 0.87 | KDM4E (0.61) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL10591379 | 0.84 | POLB (0.75) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL7263142 | 0.84 | HDAC1 (0.52) | MEN1KMT2AGAAALDH1A1LMNA | |
| SCHEMBL6637333 | 0.81 | POLB (0.81) | POLBTDP1MEN1KMT2AGAA | |
| SCHEMBL13454574 | 0.81 | RAB9A (0.63) | POLBTDP1MEN1KMT2AKDM4E | |
| SCHEMBL13593267 | 0.80 | L3MBTL1 (0.56) | POLBMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |