Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976924 | 1.00 | NAMPT (0.50) | NAMPTHDAC3NCOR2LMNAHPGD | |
| SCHEMBL6166592 | 0.89 | NAMPT (0.54) | NAMPTHDAC3LMNAHPGDHTT | |
| SCHEMBL6166590 | 0.89 | NAMPT (0.54) | NAMPTHDAC3LMNAHPGDHTT | |
| SCHEMBL6168462 | 0.85 | ALDH1A1 (0.60) | NAMPTLMNAHPGDMMP1MMP2 | |
| SCHEMBL6168453 | 0.85 | ALDH1A1 (0.60) | NAMPTLMNAHPGDMMP1MMP2 | |
| SCHEMBL7994516 | 0.84 | NAMPT (0.53) | NAMPTHDAC3NCOR2LMNAHPGD | |
| SCHEMBL7994511 | 0.84 | NAMPT (0.53) | NAMPTHDAC3NCOR2LMNAHPGD | |
| SCHEMBL7991010 | 0.82 | NAMPT (0.51) | NAMPTHDAC3NCOR2LMNAHPGD | |
| SCHEMBL7991014 | 0.82 | NAMPT (0.51) | NAMPTHDAC3NCOR2LMNAHPGD | |
| SCHEMBL6167752 | 0.80 | MMP1 (0.67) | NAMPTHDAC3NCOR2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313153-B1 | ADMINISTERING PYRIDYLACRYLAMIDE COMPOUND FOR THERAPY OF NEPHRITIS | TSUMURA & CO. (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-1000935-A1 | PYRIDYLACRYLAMIDE DERIVATIVES AND NEPHRITIS REMEDIES AND TGF-$g(b) INHIBITORS CONTAINING THE SAME | TSUMURA & CO. (JP) | 2000-05-17 | — | — | EP | disclosed |