SCHEMBL7976974

SCHEMBL7976974

CC(C)n1c2ccc(F)cc2c2cc(C(=O)O)ccc21

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 2/20 0.50
KDM4E B2RXH2 4/20 0.48
HCAR3 P49019 3/20 0.48
HPGD P15428 3/20 0.48
HCAR2 Q8TDS4 1/20 0.48
PLA2G4A P47712 2/20 0.43
ALDH1A1 P00352 2/20 0.43
SLC22A12 Q96S37 1/20 0.41
HSD17B10 Q99714 1/20 0.41
GAA P10253 1/20 0.41
PTGER4 P35408 1/20 0.41
ACE2 Q9BYF1 1/20 0.40
RORC P51449 2/20 0.40
BCL2L1 Q07817 1/20 0.40
BAD Q92934 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4726929 0.83 KDM4E (0.69) NPY5RKDM4EHCAR3HPGDHCAR2
SCHEMBL7963516 0.81 ATM (0.49) NPY5RKDM4EHPGDALDH1A1HSD17B10
SCHEMBL4726147 0.77 HPGD (0.55) NPY5RKDM4EHCAR3HPGDHCAR2
SCHEMBL27586281 0.76 MEN1 (0.56) NPY5RRORC
SCHEMBL2482006 0.74 KDM4E (0.56) NPY5RKDM4EHCAR3HPGDHCAR2
SCHEMBL30152464 0.74 CDC25B (0.55) NPY5RKDM4EALDH1A1HSD17B10GAA
SCHEMBL20294090 0.74 CDC25B (0.55) NPY5RKDM4EALDH1A1HSD17B10GAA
SCHEMBL27586361 0.72 MEN1 (0.72) NPY5RALDH1A1
SCHEMBL69291 0.71 KDM4E (0.83) KDM4EHCAR3HPGDHCAR2ALDH1A1
SCHEMBL4727525 0.71 MEN1 (0.55) NPY5RKDM4EHPGDALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001007409-A1 CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS ASTRAZENECA UK LIMITED (GB) 2001-02-01 WO disclosed